- Tom Guiry as Scott "Scotty" Smalls, new kid in town, who later becomes a left fielder for the Sandlot team.
- Mike Vitar as Benjamin Franklin "Benny" Rodriguez, leader of the group, as well as the most dedicated and skilled member of the team.
- Pablo Vitar as adult Benny "The Jet" Rodriguez
- Patrick Renna as Hamilton "Ham" Porter, overweight, short-tempered catcher.
- Chauncey Leopardi as Michael "Squints" Palledorous, glasses-wearing, snarky centerfielder.
- Marty York as Alan "Yeah-Yeah" McClennan, smart-mouthed third baseman.
- Brandon Quintin Adams as Kenny DeNunez, easygoing African American pitcher.
- Grant Gelt as Bertram Grover Weeks, rebellious second baseman.
- Victor DiMattia as Timmy Timmons, hapless first baseman, and Tommy's older brother.
- Shane Obedzinski as Tommy "Repeat" Timmons, right fielder, and Timmy's younger brother.
- Denis Leary as Bill, Scotty's stepdad
- Karen Allen as Scotty's mom
- James Earl Jones as Mr. Mertle, former player who now resides near the Sandlot, and owner of "The Beast".
- Art LaFleur as Babe Ruth "The Great Bambino", a former famous baseball star player of the New York Yankees who appears in Benny's dream to give wisdom to him on rescuing the prized baseball from "The Beast"
- Marley Shelton (credited as Marlee Shelton) as Wendy Peffercorn, lifeguard at the local pool, and target of Squints' crush.
- Wil Horneff as Little League team leader Phillips
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